As biopharmaceutical manufacturing moves toward higher productivity, greater molecule complexity, and more flexible operations, traditional resin-based chromatography can become a downstream bottleneck. Long residence times, extended column operations, and high consumable requirements can limit throughput and contribute to manufacturing costs. Membrane chromatography offers a highly efficient, alternative approach, but questions remain around process robustness, scalability, product quality, and applicability to complex molecules.

This on-demand webinar with Pharma Manufacturing will examine how Altruist Biologics’ fully characterized, mature membrane chromatography platform addresses these challenges through rapid-cycling, membrane-based purification. An integrated two-step membrane capture and polishing workflow enables increased downstream productivity while reducing consumable requirements and non-productive processing time. The platform is supported by cross-modality purification data, 200-cycle long-term operational robustness studies, and quantitative economic modeling demonstrating its potential to reduce cost of goods (COGS) in multi-product manufacturing scenarios.

Key Takeaways

-Learn how integrated membrane chromatography can provide a technically robust, linearly scalable industrialization pathway
-Gain insights from Altruist’s own platform case study with a successful validation at 200 L scale
-Assess the applicability of membrane-based purification to complex molecules