Resin Selectivity and Process Innovation for Aggregate and Fragment Control in Trispecific Antibody Project

Multispecific antibody manufacturing faces notable challenges, including high levels of aggregates and antibody fragments, which are critical quality attributes that must be tightly controlled. Co-developed by NanoMicro Technologies Inc. and Altruist Biologics, this technical whitepaper shares customer case studies on the purification of complex multispecific and trispecific antibodies, demonstrating how tailored chromatographic resin selection and optimized process innovation can efficiently remove these impurities to enable robust product quality. This systematic solution offers a practical, scalable workflow for bioprocess developers working on trispecific and other complex bispecific/multispecific antibody programs, helping teams meet regulatory requirements and accelerate biologic development timelines.